Lymphoid enhancer-binding factor 1

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Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.[1]

Function

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).[2]

Clinical significance

LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia.[3] It is also a promising potential drug target.[4]

Interactions

Lymphoid enhancer-binding factor 1 has been shown to interact with:

References

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Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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