Retinoid X receptor
| retinoid X receptor alpha | |
|---|---|
| Identifiers | |
| Symbol | RXRA |
| Entrez | 6256 |
| HUGO | 10477 |
| OMIM | 180245 |
| RefSeq | NM_002957 |
| UniProt | P19793 |
| Other data | |
| Locus | Chr. 9 q34 |
| retinoid X receptor beta | |
|---|---|
| Identifiers | |
| Symbol | RXRB |
| Entrez | 6257 |
| HUGO | 10478 |
| OMIM | 180246 |
| RefSeq | NM_021976 |
| UniProt | P28702 |
| Other data | |
| Locus | Chr. 6 p21.3 |
| retinoid X receptor gamma | |
|---|---|
| Identifiers | |
| Symbol | RXRG |
| Entrez | 6258 |
| HUGO | 10479 |
| OMIM | 180247 |
| RefSeq | NM_006917 |
| UniProt | P48443 |
| Other data | |
| Locus | Chr. 1 q22-q23 |
The retinoid X receptor (RXR)[1] is a type of nuclear receptor that is activated by 9-cis retinoic acid,[2] which has never been convincingly proven to be of physiological relevance and to be present endogenously, as well as 9-cis-13,14-dihydro-retinoic acid.[3] There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma, encoded by the RXRA, RXRB, RXRG genes, respectively.
RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR,[4] PXR, RAR, TR, and VDR.
As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.
See also
References
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<references />, or <references group="..." />External links
- Retinoid X Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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