Remimazolam

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Remimazolam
Remimazolam.svg
Systematic (IUPAC) name
methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
Identifiers
CAS Number 308242-62-8 YesY
PubChem CID: 9824461
ChemSpider 8043503 N
UNII 7V4A8U16MB YesY
Chemical data
Formula C21H19BrN4O2
Molecular mass 439.304 g/mol
  • c4cccnc4C1=NC(CCC(=O)OC)c(ncc2C)n2-c(cc3)c1cc3Br
  • InChI=1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1 N
  • Key:CYHWMBVXXDIZNZ-KRWDZBQOSA-N N
 NYesY (what is this?)  (verify)

Remimazolam[1] (CNS-7056) is a benzodiazepine derivative drug, developed by PAION, in collaboration with Japanese licensee Ono Pharmaceutical as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. Remimazolam was found to be both faster acting and shorter lasting than midazolam, and human clinical trials showed a faster recovery time and predictable, consistent pharmacokinetics, suggesting some advantages over existing drugs for these applications.[2][3]

Trials

Phase I[4] and Ib[5] dose-finding studies for procedural sedation with patients recovering faster from remimazolam than midazolam. Phase II trials comparing remimazolam to the standard anesthesia protocols for cardiac surgery and colonoscopy were presented at major conferences in October 2014.[6]

A phase IIa trial comparing remimazolam to midazolam for upper endoscopy was published in December 2014, finding a similar safety profile.[7]Remimazolam was originally discovered in the late 1990's at Glaxo Wellcome in their labs in Research Triangle Park, NC.

See also

References

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Stub icon

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  1. ↑ EP Patent 1183243
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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