Thienotriazolodiazepine

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Not to be confused with thienobenzodiazepine or thienodiazepine.
File:Thienotriazolodiazepines general structure.svg
Core structure of thienotriazolobenzodiazepines

A thienotriazolodiazepine[1] is a heterocyclic compound containing a diazepine ring fused to a thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:

Thienotriazolodiazepines interact with the benzodiazepine receptor site, they typically have similar effects as 1,4-benzodiazepines (such as diazepam) and triazolobenzodiazepines (such as alprazolam).

Thienotriazolodiazepines that are not GABAA receptor positive allosteric modulators include:

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Hirota N, Yasuda D, Hashidate T, Yamamoto T, Yamaguchi S, Nagamune T, Nagase T, Shimizu T, Nakamura M. Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. Journal of Biological Chemistry. 2010 Feb 19;285(8):5931-40. doi: 10.1074/jbc.M109.066282. PMID 20007715


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