Tetradecylthioacetic acid

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Tetradecylthioacetic acid
Tetradecylthioacetic acid.svg
Names
IUPAC name
(Tetradecylsulfanyl)acetic acid
Other names
1-(Carboxymethylthio)tetradecane
Identifiers
2921-20-2 YesY
Abbreviations TTA; CMTD
ChemSpider 102869
Jmol 3D model Interactive image
PubChem 114924
UNII 7ZU5I25S2O YesY
  • InChI=1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
    Key: IPBCWPPBAWQYOO-UHFFFAOYSA-N
  • InChI=1/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
    Key: IPBCWPPBAWQYOO-UHFFFAOYAU
  • O=C(O)CSCCCCCCCCCCCCCC
Properties
C16H32O2S
Molar mass 288.49 g·mol−1
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Tetradecylthioacetic acid (TTA) is a synthetic fatty acid used as a nutritional supplement.

TTA acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist and increases mitochondrial fatty acid oxidation in vitro.[1] In rodent studies, TTA has been reported to have other activities such as reducing inflammation[2] and preventing high fat diet induced adiposity and insulin resistance.[3]

In human clinical study, there have been mixed observations in preliminary studies. One Phase I study showed no significant changes in the blood lipids or free fatty acids[4] and another showed that TTA attenuates dyslipidemia in patients with type 2 diabetes mellitus.[1]

References

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