CD79
| CD79a molecule, immunoglobulin-associated alpha | |
|---|---|
| Identifiers | |
| Symbol | CD79A |
| Alt. symbols | IGA |
| Entrez | 973 |
| HUGO | 1698 |
| OMIM | 112205 |
| RefSeq | NM_001783 |
| UniProt | P11912 |
| Other data | |
| Locus | Chr. 19 q13.2 |
| CD79b molecule, immunoglobulin-associated beta | |
|---|---|
| Identifiers | |
| Symbol | CD79B |
| Alt. symbols | IGB |
| Entrez | 974 |
| HUGO | 1699 |
| OMIM | 147245 |
| RefSeq | NM_021602 |
| UniProt | P40259 |
| Other data | |
| Locus | Chr. 17 q23 |
CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding.[1] CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17.[1][2] Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal tranduction observed during T cell receptor activation on T cells.[3]
References
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External links
- CD79 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
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