Lortalamine

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Lortalamine
Lortalamine.svg
Lortalamine ball-and-stick model.png
Systematic (IUPAC) name
8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-4a,10-(iminoethano)-4aH-[1]-benzopyrano[3,2-c]-pyridin-12-one
Clinical data
Routes of
administration		 Oral
Pharmacokinetic data
Biological half-life 5 hours
Excretion Renal (98%)
Identifiers
CAS Number 70384-91-7
ATC code None
PubChem CID: 51047
ChemSpider 16736803
UNII 9GIR4SV22T YesY
KEGG D04781
Chemical data
Formula C15H17ClN2O2
Molecular mass 292.76 g/mol
  • Clc1ccc2O[C@]34NC(=O)C[C@@H](c2c1)[C@H]4CN(C)CC3

Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s.[1][2] It acts as a potent and highly selective norepinephrine reuptake inhibitor.[3][4] Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals.[5][6] It has been used to label the norepinephrine transporter in positron emission tomography studies.[4][7][8]

See also

References

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