Dimetacrine

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Dimetacrine
Skeletal formula of dimetacrine
Ball-and-stick model of the dimetacrine molecule
Systematic (IUPAC) name
3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
Clinical data
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Identifiers
CAS Number 4757-55-5
ATC code N06AA18 (WHO)
PubChem CID: 94280
DrugBank DB08996 YesY
ChemSpider 85085
UNII O341NY501N YesY
KEGG D02565
Chemical data
Formula C20H26N2
Molecular mass 294.43 g/mol
  • CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C

Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[1][2][3][4][5] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[6][7] Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

References

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