Piperoxan

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Piperoxan
Piperoxan.svg
Systematic (IUPAC) name
1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)piperidine
Clinical data
Legal status
  • Uncontrolled
Routes of
administration		 Oral
Identifiers
CAS Number 59-39-2
135-87-5 (hydrochloride)
ATC code none
PubChem CID: 6040
ChemSpider 5817
UNII 9ZCS27634Y YesY
ChEMBL CHEMBL31836
Chemical data
Formula C14H19NO2
Molecular mass 233.31 g/mol
  • O1c3c(OC(C1)CN2CCCCC2)cccc3

Piperoxan, also known as benodaine, is a drug which was the very first antihistamine to be discovered.[1][2] This compound, derived from benzodioxan, was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]

See also

References

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