Mepyramine

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Mepyramine
Mepyramine.svg
Systematic (IUPAC) name
N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a606008
Identifiers
CAS Number 91-84-9 YesY
Template:CAS (maleate)
ATC code R06AC01 (WHO) D04AA02
PubChem CID: 4992
IUPHAR/BPS 1227
DrugBank DB06691 N
ChemSpider 4818 YesY
UNII HPE317O9TL YesY
KEGG D08183 YesY
ChEBI CHEBI:6762 N
ChEMBL CHEMBL511 YesY
Synonyms N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
Chemical data
Formula C17H23N3O
Molecular mass 285.38 g/mol
  • O(c1ccc(cc1)CN(c2ncccc2)CCN(C)C)C
  • InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3 YesY
  • Key:YECBIJXISLIIDS-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

Synthesis

Pyrilamine synthesis:[3][4][5]

See also

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Active Ingredients for Midol Complete
  3. R.J. Horclois, U.S. Patent 2,502,151 (1950).
  4. Lua error in package.lua at line 80: module 'strict' not found.
  5. D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).


<templatestyles src="Asbox/styles.css"></templatestyles>

<templatestyles src="Asbox/styles.css"></templatestyles>