Gallamine triethiodide

Gallamine triethiodide

File:Gallamine triethiodide.svg
Systematic (IUPAC) name
2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide
Clinical data
Trade names	Flaxedil
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	65-29-2 Y
ATC code	M03AC02 (WHO)
PubChem	CID: 6172
IUPHAR/BPS	356
DrugBank	DB00483 Y
ChemSpider	5937 N
UNII	Q3254X40X2 Y
KEGG	D02292 Y
ChEBI	CHEBI:503442 Y
ChEMBL	CHEMBL1200993 N
Chemical data
Formula	C30H60N3O3+3 · 3 I− (gallamine triethiodide) C24H45N3O3 (gallamine)
Molecular mass	891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine)
SMILES [I-].[I-].[I-].O(c1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)CC[N+](CC)(CC)CC
InChI InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 Y Key:ICLWTJIMXVISSR-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

File:Flaxedil.png

An ampoule of gallamine.