Talsaclidine

Talsaclidine

Systematic (IUPAC) name
(3R)-3-(prop-2-yn-1-yloxy)-1-azabicyclo[2.2.2]octane
Pharmacokinetic data
Bioavailability	70%
Protein binding	7%
Excretion	Renal (86%)
Identifiers
CAS Number	147025-53-4
ATC code	none
PubChem	CID: 71792
ChemSpider	64819
UNII	1O8VSL798T Y
Chemical data
Formula	C10H15NO
Molecular mass	165.23 g/mol
SMILES O([C@@H]2C1CCN(CC1)C2)CC#C

Talsaclidine (WAL-2014) is a non-selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M₁ subtype, and as a partial agonist at the M₂ and M₃ subtypes. It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans, respectively, perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure, increased salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation, heartburn, upset stomach as well as cramps, nausea, vomiting and diarrhea, excessive sweating and palpitations.

See also

• Aceclidine
• Vedaclidine