Nelotanserin

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Nelotanserin
File:Nelotanserin structure.png
Systematic (IUPAC) name
1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 839713-36-9 YesY
ATC code none
PubChem CID: 11683556
ChemSpider 9858284 N
UNII 4ZA73QEW2P N
Chemical data
Formula C18H15BrF2N4O2
Molecular mass 437.238 g/mol
  • Brc1cnn(C)c1-c2cc(ccc2OC)NC(=O)Nc3ccc(F)cc3F
  • InChI=1S/C18H15BrF2N4O2/c1-25-17(13(19)9-22-25)12-8-11(4-6-16(12)27-2)23-18(26)24-15-5-3-10(20)7-14(15)21/h3-9H,1-2H3,(H2,23,24,26) N
  • Key:COSPVUFTLGQDQL-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Nelotanserin (APD-125) is a drug developed by Arena Pharmaceuticals which acts as an inverse agonist on the serotonin receptor subtype 5-HT2A.[1] It was shown to be effective and well tolerated in clinical trials,[2][3] but development was halted in December 2008 because the substance did not meet the trial's endpoints.[4] Research continues on newer analogues which may potentially be more successful.[5]



References

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ APD125 for Insomnia
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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