TFMFly

TFMFly

Systematic (IUPAC) name
(2R)-1-(8-trifluoromethyl-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran-4-yl)-2-aminoethane
Identifiers
CAS Number	780744-19-6 Y 332012-20-1 (hydrochloride)
PubChem	CID: 10782206
Chemical data
Formula	C14H16F3NO2
Molecular mass	287.277 g/mol
SMILES c13OCCc3c(C(F)(F)F)c2OCCc2c1CC(C)N
(verify)

TFMFly is a compound related to psychedelic phenethylamines such as 2C-B-FLY and 2C-TFM. It was first reported in 2005 by a team at Purdue University led by David Nichols. It acts as a potent agonist at the 5HT_2A serotonin receptor subtype, and is a chiral compound with the more active (R) enantiomer having a Ki of 0.12nM at the human 5HT_2A receptor. While the fully aromatic benzodifurans such as bromodragonfly generally have higher binding affinity than saturated compounds like 2C-B-FLY, the saturated compounds have higher efficacy as agonists.

Legal Status

TFMFly is illegal in Latvia.